The ubiquitin code.
نویسندگان
چکیده
The posttranslational modification with ubiquitin, a process referred to as ubiquitylation, controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a single moiety or in the form of polymeric chains in which successive ubiquitin molecules are connected through specific isopeptide bonds. Reminiscent of a code, the various ubiquitin modifications adopt distinct conformations and lead to different outcomes in cells. Here, we discuss the structure, assembly, and function of this ubiquitin code.
منابع مشابه
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عنوان ژورنال:
- Annual review of biochemistry
دوره 81 شماره
صفحات -
تاریخ انتشار 2012